Assay Detail
Functional
CHEMBL5584490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human WSUDLCL2 cells harboring EZH2 Y641F mutant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WSUDLCL2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.58 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598486 | — | — | 1 | 8.87 |
| CHEMBL5596732 | — | — | 1 | 8.72 |
| CHEMBL5598282 | — | — | 1 | 8.63 |
| CHEMBL5596736 | — | — | 1 | 8.62 |
| CHEMBL5598381 | — | — | 1 | 8.45 |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598486 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL5596732 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5598282 | — | IC50 | = | 2.36 | nM | 8.63 |
| CHEMBL5596736 | — | IC50 | = | 2.38 | nM | 8.62 |
| CHEMBL5598381 | — | IC50 | = | 3.58 | nM | 8.45 |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | = | 6.44 | nM | 8.19 |