Assay Detail
Functional
CHEMBL5584635
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Antiproliferative activity against human HuH-1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuH-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological activity evaluation and mechanism of action of novel bis-isatin derivatives as potential anti-liver cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.71 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.02 |
| CHEMBL5596474 | — | — | 1 | 4.77 |
| CHEMBL5596588 | — | — | 1 | 4.58 |
| CHEMBL5596933 | — | — | 1 | 4.46 |
| CHEMBL5596615 | — | — | 1 | - |
| CHEMBL5598201 | — | — | 1 | - |
| CHEMBL5598210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL5596474 | — | IC50 | = | 17130.0 | nM | 4.77 |
| CHEMBL5596588 | — | IC50 | = | 26370.0 | nM | 4.58 |
| CHEMBL5596933 | — | IC50 | = | 35060.0 | nM | 4.46 |
| CHEMBL5596615 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5598201 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5598210 | — | IC50 | > | 100000.0 | nM | - |