Assay Detail
Binding
CHEMBL5584774
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Inhibition of ALK (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in c-Met-based dual inhibitors in the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.37 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598386 | — | — | 1 | 9.62 |
| CHEMBL5590922 | — | — | 1 | 9.48 |
| CHEMBL5596179 | — | — | 1 | 8.80 |
| CHEMBL5596051 | — | — | 1 | 8.73 |
| CHEMBL5597352 | — | — | 1 | 8.11 |
| CHEMBL5596073 | — | — | 1 | 8.10 |
| CHEMBL5597248 | — | — | 1 | 7.69 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.55 |
| CHEMBL5596227 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598386 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5590922 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL5596179 | — | IC50 | = | 1.59 | nM | 8.80 |
| CHEMBL5596051 | — | IC50 | = | 1.88 | nM | 8.73 |
| CHEMBL5597352 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5596073 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5597248 | — | IC50 | = | 20.31 | nM | 7.69 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5596227 | — | IC50 | = | 60.0 | nM | 7.22 |