Assay Detail
Functional
CHEMBL5584837
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Antiproliferative activity against human KB-3-1 cells assessed as cell growth inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in c-Met-based dual inhibitors in the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989914 | GLESATINIB | 2.0 | 1 | 8.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.22 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989914 | GLESATINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1900.0 | nM | 5.72 |