Assay Detail
Functional
CHEMBL5584936
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 1 hr by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of a new short anticancer peptide with good potential for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.84 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412927 | MELITTIN | — | 1 | 5.75 |
| CHEMBL5597528 | — | — | 1 | 5.40 |
| CHEMBL5598040 | — | — | 1 | 5.33 |
| CHEMBL5596278 | — | — | 1 | 5.32 |
| CHEMBL5589747 | — | — | 1 | 5.23 |
| CHEMBL5591300 | — | — | 1 | 5.21 |
| CHEMBL5596081 | — | — | 1 | 5.13 |
| CHEMBL5596119 | — | — | 1 | 5.12 |
| CHEMBL5598197 | — | — | 1 | 5.07 |
| CHEMBL5596674 | — | — | 1 | 5.04 |
| CHEMBL5596841 | — | — | 1 | 4.98 |
| CHEMBL5598335 | — | — | 1 | 4.98 |
| CHEMBL5590181 | — | — | 1 | 4.93 |
| CHEMBL5598509 | — | — | 1 | 4.90 |
| CHEMBL5596777 | — | — | 1 | 4.85 |
| CHEMBL5596860 | — | — | 1 | 4.80 |
| CHEMBL5596501 | — | — | 1 | 4.73 |
| CHEMBL5596905 | — | — | 1 | 4.67 |
| CHEMBL5598327 | — | — | 1 | 4.67 |
| CHEMBL5597709 | — | — | 1 | 4.51 |
| CHEMBL5590137 | — | — | 1 | 4.40 |
| CHEMBL5598167 | — | — | 1 | 4.29 |
| CHEMBL5598146 | — | — | 1 | 4.23 |
| CHEMBL4297628 | RUXOTEMITIDE | 2.0 | 1 | 4.20 |
| CHEMBL5596132 | — | — | 1 | 4.05 |
| CHEMBL5596621 | — | — | 1 | 4.01 |
| CHEMBL5596207 | — | — | 1 | - |
| CHEMBL5596984 | — | — | 1 | - |
| CHEMBL5597409 | — | — | 1 | - |
| CHEMBL5597210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412927 | MELITTIN | IC50 | = | 1793.0 | nM | 5.75 |
| CHEMBL5597528 | — | IC50 | = | 3947.0 | nM | 5.40 |
| CHEMBL5598040 | — | IC50 | = | 4672.0 | nM | 5.33 |
| CHEMBL5596278 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL5589747 | — | IC50 | = | 5877.0 | nM | 5.23 |
| CHEMBL5591300 | — | IC50 | = | 6187.0 | nM | 5.21 |
| CHEMBL5596081 | — | IC50 | = | 7458.0 | nM | 5.13 |
| CHEMBL5596119 | — | IC50 | = | 7655.0 | nM | 5.12 |
| CHEMBL5598197 | — | IC50 | = | 8546.0 | nM | 5.07 |
| CHEMBL5596674 | — | IC50 | = | 9056.0 | nM | 5.04 |
| CHEMBL5596841 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5598335 | — | IC50 | = | 10450.0 | nM | 4.98 |
| CHEMBL5590181 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL5598509 | — | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL5596777 | — | IC50 | = | 13980.0 | nM | 4.85 |
| CHEMBL5596860 | — | IC50 | = | 15670.0 | nM | 4.80 |
| CHEMBL5596501 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5596905 | — | IC50 | = | 21390.0 | nM | 4.67 |
| CHEMBL5598327 | — | IC50 | = | 21430.0 | nM | 4.67 |
| CHEMBL5597709 | — | IC50 | = | 30710.0 | nM | 4.51 |
| CHEMBL5590137 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL5598167 | — | IC50 | = | 51210.0 | nM | 4.29 |
| CHEMBL5598146 | — | IC50 | = | 58360.0 | nM | 4.23 |
| CHEMBL4297628 | RUXOTEMITIDE | IC50 | = | 63460.0 | nM | 4.20 |
| CHEMBL5596132 | — | IC50 | = | 89690.0 | nM | 4.05 |
| CHEMBL5596621 | — | IC50 | = | 97060.0 | nM | 4.01 |
| CHEMBL5596207 | — | IC50 | = | 100600.0 | nM | - |
| CHEMBL5596984 | — | IC50 | = | 181400.0 | nM | - |
| CHEMBL5597409 | — | IC50 | = | 202400.0 | nM | - |
| CHEMBL5597210 | — | IC50 | = | 108400.0 | nM | - |