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Assay Detail

CHEMBL5585016

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAL-51
Confidence 1 — Organism
Curated By Autocuration

Target

CAL-51 (CHEMBL1075411)
Type CELL-LINE
Organism Homo sapiens

Publication

Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents.
Liang C, Zhou Y, Xin L, Kang K, Tian L, Zhang D, Li H, Zhao Q, Gao H, Shi Z.
Eur J Med Chem (2024) 273 : 116504 -116504
PubMed 38795520 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.31 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4086674 1 8.10
CHEMBL4060730 1 8.05
CHEMBL4068490 1 7.89
CHEMBL4090966 1 7.82
CHEMBL4086004 1 7.77
CHEMBL4097084 1 7.75
CHEMBL4063065 1 7.70
CHEMBL4095765 1 7.52
CHEMBL4066315 1 7.40
CHEMBL4080975 1 7.22
CHEMBL4062218 1 7.22
CHEMBL4099734 1 7.16
CHEMBL4065773 1 7.00
CHEMBL4074116 1 6.92
CHEMBL4063994 1 6.40
CHEMBL4090356 1 6.30
CHEMBL4064411 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4086674 IC50 = 8.0 nM 8.10
CHEMBL4060730 IC50 = 9.0 nM 8.05
CHEMBL4068490 IC50 = 13.0 nM 7.89
CHEMBL4090966 IC50 = 15.0 nM 7.82
CHEMBL4086004 IC50 = 17.0 nM 7.77
CHEMBL4097084 IC50 = 18.0 nM 7.75
CHEMBL4063065 IC50 = 20.0 nM 7.70
CHEMBL4095765 IC50 = 30.0 nM 7.52
CHEMBL4066315 IC50 = 40.0 nM 7.40
CHEMBL4080975 IC50 = 60.0 nM 7.22
CHEMBL4062218 IC50 = 60.0 nM 7.22
CHEMBL4099734 IC50 = 70.0 nM 7.16
CHEMBL4065773 IC50 = 100.0 nM 7.00
CHEMBL4074116 IC50 = 120.0 nM 6.92
CHEMBL4063994 IC50 = 400.0 nM 6.40
CHEMBL4090356 IC50 = 500.0 nM 6.30
CHEMBL4064411 IC50 = 770.0 nM 6.11