Assay Detail
Functional
CHEMBL5585252
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Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.93 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597526 | — | — | 1 | 6.34 |
| CHEMBL5598141 | — | — | 1 | 6.10 |
| CHEMBL5597533 | — | — | 1 | 6.06 |
| CHEMBL5597674 | — | — | 1 | 6.04 |
| CHEMBL5596963 | — | — | 1 | 5.90 |
| CHEMBL5598003 | — | — | 1 | 5.83 |
| CHEMBL5598552 | — | — | 1 | 5.62 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597526 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5598141 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5597533 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5597674 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5596963 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5598003 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5598552 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2860.0 | nM | 5.54 |