Assay Detail
Toxicity
CHEMBL5585351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fluorescence tracer red binding to human ERG measured after 3 hrs by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, biological evaluation, and in silico studies of novel pyridopyridine derivatives as anticancer candidates targeting FMS kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.31 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536480 | — | — | 1 | 7.83 |
| CHEMBL5598552 | — | — | 1 | 4.08 |
| CHEMBL5598003 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536480 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5598552 | — | IC50 | = | 83450.0 | nM | 4.08 |
| CHEMBL5598003 | — | IC50 | = | 95900.0 | nM | 4.02 |