Assay Detail
Binding
CHEMBL5585360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs by microplate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Psammaplin A analogues with modified disulfide bond targeting histone deacetylases: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83747 | PSAMMAPLIN A | — | 1 | 7.58 |
| CHEMBL4746691 | — | — | 1 | 6.77 |
| CHEMBL5597268 | — | — | 1 | 6.24 |
| CHEMBL5596769 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83747 | PSAMMAPLIN A | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4746691 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5597268 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5596769 | — | IC50 | = | 770.0 | nM | 6.11 |