Assay Detail
Binding
CHEMBL5585482
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Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D-glucopyranoside as substrate incubated for 15 to 25 mins by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.04 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 5.91 |
| CHEMBL5597113 | — | — | 1 | 5.86 |
| CHEMBL5597693 | — | — | 1 | 5.53 |
| CHEMBL5597515 | — | — | 1 | 5.29 |
| CHEMBL5596134 | — | — | 1 | 4.96 |
| CHEMBL5596823 | — | — | 1 | 4.74 |
| CHEMBL5596261 | — | — | 1 | 4.72 |
| CHEMBL5596871 | — | — | 1 | 4.36 |
| CHEMBL5596319 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404271 | ACARBOSE | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5597113 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5597693 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5597515 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL5596134 | — | IC50 | = | 11010.0 | nM | 4.96 |
| CHEMBL5596823 | — | IC50 | = | 18310.0 | nM | 4.74 |
| CHEMBL5596261 | — | IC50 | = | 19130.0 | nM | 4.72 |
| CHEMBL5596871 | — | IC50 | = | 44050.0 | nM | 4.36 |
| CHEMBL5596319 | — | IC50 | = | 96520.0 | nM | 4.01 |