Assay Detail
Binding
CHEMBL5585743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5-HT6 receptor extracted from HEK293 cell membrane by microbeta plate reader analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.14 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598162 | — | — | 1 | 9.00 |
| CHEMBL5596350 | — | — | 1 | 9.00 |
| CHEMBL5597256 | — | — | 1 | 9.00 |
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 8.89 |
| CHEMBL5596691 | — | — | 1 | 8.70 |
| CHEMBL5597727 | — | — | 1 | 8.70 |
| CHEMBL5596980 | — | — | 1 | 8.40 |
| CHEMBL5597355 | — | — | 1 | 8.40 |
| CHEMBL5597650 | — | — | 1 | 8.40 |
| CHEMBL5596555 | — | — | 1 | 8.10 |
| CHEMBL5598097 | — | — | 1 | 7.90 |
| CHEMBL5597198 | — | — | 1 | 7.60 |
| CHEMBL5597699 | — | — | 1 | 7.57 |
| CHEMBL5597062 | — | — | 1 | 7.38 |
| CHEMBL5596507 | — | — | 1 | 7.35 |
| CHEMBL5598057 | — | — | 1 | 7.16 |
| CHEMBL5597928 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598162 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5596350 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5597256 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL5596691 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5597727 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5596980 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5597355 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5597650 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5596555 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5598097 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL5597198 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5597699 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL5597062 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL5596507 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL5598057 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL5597928 | — | Ki | = | 124.0 | nM | 6.91 |