Assay Detail
Binding
CHEMBL5585745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ketanserin from human 5-HT2A receptor extracted from CHO-K1 cell membrane by microbeta plate reader analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.91 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 7.60 |
| CHEMBL5596350 | — | — | 1 | 6.38 |
| CHEMBL5597256 | — | — | 1 | 6.18 |
| CHEMBL5597355 | — | — | 1 | 5.81 |
| CHEMBL5598162 | — | — | 1 | 5.60 |
| CHEMBL5598097 | — | — | 1 | 4.97 |
| CHEMBL5597699 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 25.1 | nM | 7.60 |
| CHEMBL5596350 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL5597256 | — | Ki | = | 655.0 | nM | 6.18 |
| CHEMBL5597355 | — | Ki | = | 1538.0 | nM | 5.81 |
| CHEMBL5598162 | — | Ki | = | 2505.0 | nM | 5.60 |
| CHEMBL5598097 | — | Ki | = | 10590.0 | nM | 4.97 |
| CHEMBL5597699 | — | Ki | = | 15860.0 | nM | 4.80 |