Assay Detail
Binding
CHEMBL5585746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-CT from human 5-HT7 receptor extracted from HEK293 cell membrane by microbeta plate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.07 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597699 | — | — | 1 | 5.88 |
| CHEMBL5597355 | — | — | 1 | 5.70 |
| CHEMBL5598162 | — | — | 1 | 4.94 |
| CHEMBL5597256 | — | — | 1 | 4.93 |
| CHEMBL5596350 | — | — | 1 | 4.91 |
| CHEMBL5598097 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597699 | — | Ki | = | 1316.0 | nM | 5.88 |
| CHEMBL5597355 | — | Ki | = | 1986.0 | nM | 5.70 |
| CHEMBL5598162 | — | Ki | = | 11530.0 | nM | 4.94 |
| CHEMBL5597256 | — | Ki | = | 11630.0 | nM | 4.93 |
| CHEMBL5596350 | — | Ki | = | 12280.0 | nM | 4.91 |
| CHEMBL5598097 | — | Ki | = | 83960.0 | nM | 4.08 |