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Assay Detail

CHEMBL5585764

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against rat PC12 cells incubated for 3 hrs by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Rattus norvegicus
Cell Type PC-12
Confidence 1 — Organism
Curated By Autocuration

Target

PC-12 (CHEMBL612556)
Type CELL-LINE
Organism Rattus norvegicus

Publication

5-HT<sub>6</sub> receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives.
Drop M, Koczurkiewicz-Adamczyk P, Bento O, Pietruś W, Satała G, Blicharz-Futera K, Canale V, Grychowska K, Bantreil X, Pękala E, Kurczab R, Bojarski AJ, Chaumont-Dubel S, Marin P, Lamaty F, Zajdel P.
Eur J Med Chem (2024) 275 : 116615 -116615
PubMed 38936149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.59 4.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5598162 1 4.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5598162 IC50 = 25600.0 nM 4.59