Assay Detail
Functional
CHEMBL5586010
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Antileishmanial activity against Leishmania donovani axenic amastigotes assessed as reduction in parasite growth incubated for 72 hrs by alamar blue dye based fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.85 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597520 | — | — | 1 | 6.06 |
| CHEMBL5596663 | — | — | 1 | 6.04 |
| CHEMBL5596772 | — | — | 1 | 6.01 |
| CHEMBL5596255 | — | — | 1 | 5.73 |
| CHEMBL5596258 | — | — | 1 | 5.67 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597520 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5596663 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5596772 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5596255 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5596258 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 2670.0 | nM | 5.57 |