Assay Detail
Functional
CHEMBL5586016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani amastigotes infected in human THP-1 cells assessed as reduction in parasite growth incubated for 72 hrs by alamar blue dye based fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.43 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597520 | — | — | 1 | 5.69 |
| CHEMBL5596772 | — | — | 1 | 5.65 |
| CHEMBL5596258 | — | — | 1 | 5.38 |
| CHEMBL5596255 | — | — | 1 | 5.33 |
| CHEMBL5596663 | — | — | 1 | 5.30 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597520 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5596772 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5596258 | — | EC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL5596255 | — | EC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL5596663 | — | EC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 5970.0 | nM | 5.22 |