Assay Detail
Binding
CHEMBL5586042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AHR stably tranfected in HEK293-T-REx cells co-expressing EGFP assessed as increase in AHR nuclear translocation incubated for 45 mins by Hoechst staining based fluorescence imaging analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-T-REx |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel AHR Agonists for Treating Psoriasis and Atopic Dermatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.59 | 9.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597486 | — | — | 1 | 9.81 |
| CHEMBL5597246 | — | — | 1 | 9.64 |
| CHEMBL5589840 | — | — | 1 | 9.62 |
| CHEMBL5596667 | — | — | 1 | 9.55 |
| CHEMBL5597439 | — | — | 1 | 9.55 |
| CHEMBL5596304 | — | — | 1 | 9.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597486 | — | EC50 | = | 0.154 | nM | 9.81 |
| CHEMBL5597246 | — | EC50 | = | 0.227 | nM | 9.64 |
| CHEMBL5589840 | — | EC50 | = | 0.237 | nM | 9.62 |
| CHEMBL5596667 | — | EC50 | = | 0.279 | nM | 9.55 |
| CHEMBL5597439 | — | EC50 | = | 0.283 | nM | 9.55 |
| CHEMBL5596304 | — | EC50 | = | 0.404 | nM | 9.39 |