Assay Detail
Binding
CHEMBL5586086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (E)-N6-(5-(bis(4-chlorophenyl)methyl)thiazol-2-yl)-N2-(6-(2-(4-(2-(5,5-difluoro-7-(thiophen-2-yl)-5H-4lambda4,5lambda4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)vinyl)phenoxy)acetamido)hexanoyl)-L-lysine from NLuc fused P2Y2R (unknown origin) extracted from 1321N1 cell membrane incubated for 1 hr by NanoBRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321N1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y<sub>2</sub> Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.68 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128059 | — | — | 1 | 5.04 |
| CHEMBL5596941 | — | — | 1 | 4.86 |
| CHEMBL4082045 | — | — | 1 | 4.14 |
| CHEMBL5597711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128059 | — | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL5596941 | — | Ki | = | 13803.84 | nM | 4.86 |
| CHEMBL4082045 | — | Ki | = | 72443.6 | nM | 4.14 |
| CHEMBL5597711 | — | Ki | = | 120226.44 | nM | - |