Assay Detail
Functional
CHEMBL5586175
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Induction of Vgamma9Vdelta2 T cell activation in human PBMC cells incubated for 3 days followed by compound washout and measured after 11 days by flow cytometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.35 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597946 | — | — | 1 | 9.29 |
| CHEMBL145233 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597946 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL145233 | — | EC50 | = | 4000.0 | nM | 5.40 |