Assay Detail
Functional
CHEMBL5586205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against PYR-resistant Plasmodium falciparum V1/S expressing DHFR N51I/C59R/S108N/I164L quadruple mutant by [3H]-hypoxanthine incorporation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel flexible biphenyl <i>Pf</i>DHFR inhibitors with improved antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.25 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3040038 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3040038 | — | IC50 | = | 56.0 | nM | 7.25 |