Assay Detail
Functional
CHEMBL5586743
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.76 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.58 |
| CHEMBL5596692 | — | — | 1 | 5.47 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.41 |
| CHEMBL5596125 | — | — | 1 | 5.40 |
| CHEMBL5597909 | — | — | 1 | 5.16 |
| CHEMBL5589998 | — | — | 1 | 5.12 |
| CHEMBL5597603 | — | — | 1 | 5.06 |
| CHEMBL5597035 | — | — | 1 | 4.96 |
| CHEMBL5596612 | — | — | 1 | 4.96 |
| CHEMBL5597884 | — | — | 1 | 4.77 |
| CHEMBL5596951 | — | — | 1 | 4.69 |
| CHEMBL5598249 | — | — | 1 | 4.69 |
| CHEMBL5597114 | — | — | 1 | 4.69 |
| CHEMBL5596780 | — | — | 1 | 4.69 |
| CHEMBL5597692 | — | — | 1 | 4.69 |
| CHEMBL5596080 | — | — | 1 | 4.69 |
| CHEMBL5597751 | — | — | 1 | 4.69 |
| CHEMBL5598189 | — | — | 1 | 4.69 |
| CHEMBL5596229 | — | — | 1 | 4.69 |
| CHEMBL5596776 | — | — | 1 | 4.69 |
| CHEMBL5597696 | — | — | 1 | 4.69 |
| CHEMBL5598506 | — | — | 1 | 4.69 |
| CHEMBL5596817 | — | — | 1 | 4.69 |
| CHEMBL5597863 | — | — | 1 | 4.69 |
| CHEMBL5597338 | — | — | 1 | 4.60 |
| CHEMBL5596281 | — | — | 1 | 4.58 |
| CHEMBL5597082 | — | — | 1 | 4.57 |
| CHEMBL5597384 | — | — | 1 | 4.56 |
| CHEMBL5596936 | — | — | 1 | 4.51 |
| CHEMBL5597204 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5596692 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5596125 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5597909 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5589998 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5597603 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5596612 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5597035 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL5597884 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL5598249 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597114 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596780 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597692 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596080 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597751 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5598189 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596951 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596776 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597696 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5598506 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596817 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597863 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5596229 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5597338 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL5596281 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL5597082 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL5597384 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL5596936 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL5597204 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5596332 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL5597700 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL5596272 | — | IC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL5597401 | — | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL5597230 | — | IC50 | = | 57000.0 | nM | 4.24 |