Assay Detail
Functional
CHEMBL5586744
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.30 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597909 | — | — | 1 | 5.70 |
| CHEMBL5596692 | — | — | 1 | 5.60 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.52 |
| CHEMBL5589998 | — | — | 1 | 5.42 |
| CHEMBL5596125 | — | — | 1 | 5.37 |
| CHEMBL5597035 | — | — | 1 | 5.24 |
| CHEMBL5597603 | — | — | 1 | 5.09 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.96 |
| CHEMBL5596612 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597909 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5596692 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5589998 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5596125 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5597035 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5597603 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5596612 | — | IC50 | = | 15070.0 | nM | 4.82 |