Assay Detail
Functional
CHEMBL5586745
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Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.04 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | — | 1 | 5.66 |
| CHEMBL5597909 | — | — | 1 | 5.43 |
| CHEMBL5596125 | — | — | 1 | 5.10 |
| CHEMBL5596692 | — | — | 1 | 5.05 |
| CHEMBL5589998 | — | — | 1 | 4.96 |
| CHEMBL5597603 | — | — | 1 | 4.83 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.83 |
| CHEMBL5597035 | — | — | 1 | 4.74 |
| CHEMBL5596612 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5597909 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5596125 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5596692 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5589998 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5597603 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL5597035 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL5596612 | — | IC50 | = | 19200.0 | nM | 4.72 |