Assay Detail
Toxicity
CHEMBL5586746
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.09 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | — | 1 | 6.10 |
| CHEMBL5597603 | — | — | 1 | 5.09 |
| CHEMBL5596692 | — | — | 1 | 5.08 |
| CHEMBL5589998 | — | — | 1 | 5.02 |
| CHEMBL5597909 | — | — | 1 | 4.81 |
| CHEMBL5596125 | — | — | 1 | 4.80 |
| CHEMBL5597035 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5597603 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5596692 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5589998 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5597909 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5596125 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5597035 | — | IC50 | = | 17500.0 | nM | 4.76 |