Assay Detail
Binding
CHEMBL5586929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Mcl-1 (unknown origin) pre-incubated for 30 mins followed by addition FAM-peptide further incubated for 20 mins by fluorescence polarization-based binding assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1<i>H</i>-indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 6.90 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 7.92 |
| CHEMBL5596340 | — | — | 1 | 7.62 |
| CHEMBL5598497 | — | — | 1 | 7.57 |
| CHEMBL5597184 | — | — | 1 | 7.54 |
| CHEMBL5598253 | — | — | 1 | 7.43 |
| CHEMBL5597453 | — | — | 1 | 7.37 |
| CHEMBL5598470 | — | — | 1 | 7.35 |
| CHEMBL5596228 | — | — | 1 | 7.32 |
| CHEMBL5598198 | — | — | 1 | 7.29 |
| CHEMBL5598101 | — | — | 1 | 7.26 |
| CHEMBL5591262 | — | — | 1 | 7.25 |
| CHEMBL5589824 | — | — | 1 | 7.24 |
| CHEMBL5598100 | — | — | 1 | 7.23 |
| CHEMBL5596118 | — | — | 1 | 7.22 |
| CHEMBL5597362 | — | — | 1 | 7.17 |
| CHEMBL5597331 | — | — | 1 | 7.06 |
| CHEMBL5596761 | — | — | 1 | 7.05 |
| CHEMBL5597821 | — | — | 1 | 7.02 |
| CHEMBL5598402 | — | — | 1 | 7.01 |
| CHEMBL5596331 | — | — | 1 | 7.00 |
| CHEMBL5596249 | — | — | 1 | 6.92 |
| CHEMBL5596655 | — | — | 1 | 6.92 |
| CHEMBL5596126 | — | — | 1 | 6.82 |
| CHEMBL5597099 | — | — | 1 | 6.82 |
| CHEMBL5598466 | — | — | 1 | 6.82 |
| CHEMBL5597895 | — | — | 1 | 6.82 |
| CHEMBL5596613 | — | — | 1 | 6.80 |
| CHEMBL5597673 | — | — | 1 | 6.75 |
| CHEMBL5597387 | — | — | 1 | 6.72 |
| CHEMBL3417694 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5596340 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL5598497 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL5597184 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5598253 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL5597453 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL5598470 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL5596228 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL5598198 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL5598101 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL5591262 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL5589824 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL5598100 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL5596118 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL5597362 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL5597331 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL5596761 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL5597821 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL5598402 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL5596331 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5596249 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5596655 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5596126 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5597895 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5597099 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5598466 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5596613 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL5597673 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL5597387 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3417694 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL5596355 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL5596515 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL5596354 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL5598278 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL5597585 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL5598418 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL5596206 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL5597752 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL5598182 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL5596754 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL2314193 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL5597484 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL5598447 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL5597551 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5598173 | — | Ki | - | — | - |