Assay Detail
Binding
CHEMBL5586931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Bcl-2 (unknown origin) pre-incubated for 30 mins followed by addition FAM-peptide further incubated for 20 mins by fluorescence polarization-based binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1<i>H</i>-indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.80 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 6.80 |
| CHEMBL5598253 | — | — | 1 | - |
| CHEMBL5598470 | — | — | 1 | - |
| CHEMBL5597184 | — | — | 1 | - |
| CHEMBL5596340 | — | — | 1 | - |
| CHEMBL3417704 | — | — | 1 | - |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5598253 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5598470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5597184 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5596340 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3417704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3137309 | VENETOCLAX | IC50 | > | 100000.0 | nM | - |