Assay Detail
Functional
CHEMBL5586936
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Antiproliferative activity against human U-937 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1<i>H</i>-indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.21 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417704 | — | — | 1 | 5.33 |
| CHEMBL5596340 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417704 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL5596340 | — | IC50 | = | 8330.0 | nM | 5.08 |