Assay Detail
Binding
CHEMBL5587075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged PP5 (169 to 499 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using pNPP as substrate incubated for 30 mins
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tissue factor pathway inhibitor 2 (CHEMBL6066240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.98 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597580 | — | — | 1 | 6.05 |
| CHEMBL428650 | ENDOTHALL | — | 1 | 5.51 |
| CHEMBL5596734 | — | — | 1 | 5.44 |
| CHEMBL5596696 | — | — | 1 | 5.39 |
| CHEMBL5597886 | — | — | 1 | 5.27 |
| CHEMBL5596039 | — | — | 1 | 5.21 |
| CHEMBL5598389 | — | — | 1 | 5.21 |
| CHEMBL5597987 | — | — | 1 | 5.17 |
| CHEMBL5597468 | — | — | 1 | 5.14 |
| CHEMBL5598083 | — | — | 1 | 5.11 |
| CHEMBL5598075 | — | — | 1 | 5.11 |
| CHEMBL5597434 | — | — | 1 | 5.07 |
| CHEMBL5597115 | — | — | 1 | 4.94 |
| CHEMBL5597001 | — | — | 1 | 4.76 |
| CHEMBL5596690 | — | — | 1 | 4.65 |
| CHEMBL5597671 | — | — | 1 | 4.57 |
| CHEMBL5596676 | — | — | 1 | 4.39 |
| CHEMBL5598406 | — | — | 1 | 4.27 |
| CHEMBL5596433 | — | — | 1 | 4.23 |
| CHEMBL5597836 | — | — | 1 | 4.11 |
| CHEMBL5596464 | — | — | 1 | - |
| CHEMBL5598044 | — | — | 1 | - |
| CHEMBL5598087 | — | — | 1 | - |
| CHEMBL5597525 | — | — | 1 | - |
| CHEMBL5597048 | — | — | 1 | - |
| CHEMBL5596793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597580 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL428650 | ENDOTHALL | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5596734 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5596696 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5597886 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5596039 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5598389 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5597987 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5597468 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5598083 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5598075 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5597434 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5597115 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5597001 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5596690 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL5597671 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL5596676 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL5598406 | — | IC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL5596433 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL5597836 | — | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL5596464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5598044 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5598087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5597525 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5597048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5596793 | — | IC50 | = | 463000.0 | nM | - |