Assay Detail
Binding
CHEMBL5587077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PP2A in human U-87 MG cell lysate using RRA(pT)VA as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87 MG |
| Subcellular | Lysate |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.24 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597987 | — | — | 1 | 6.00 |
| CHEMBL5597580 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597987 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5597580 | — | IC50 | = | 33800.0 | nM | 4.47 |