Assay Detail
Binding
CHEMBL5587148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PP5 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tissue factor pathway inhibitor 2 (CHEMBL6066240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | — | 1 | 9.00 |
| CHEMBL280487 | OKADAIC ACID | — | 1 | 8.46 |
| CHEMBL108308 | NODULARIN | — | 1 | 8.40 |
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.30 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444092 | MICROCYSTIN-LR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL280487 | OKADAIC ACID | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL108308 | NODULARIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 970.0 | nM | 6.01 |