Assay Detail
Binding
CHEMBL5587335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR Del19/T790M/C797S triple mutant in mouse BaF3 cells assessed as reduction in cell growth
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.40 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537790 | — | — | 1 | 9.22 |
| CHEMBL4519157 | — | — | 1 | 8.52 |
| CHEMBL4434788 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537790 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4519157 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4434788 | — | IC50 | = | 35.0 | nM | 7.46 |