Assay Detail
Binding
CHEMBL5587489
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Inhibition of SARS CoV-1 MPro using Boc-Abu-Tle-Leu-Gln-AMC as substrate incubated for 10 mins by fluorescence based assay
17
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 16 | - | - |
| IC50 | 1 | 8.29 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222735 | — | — | 2 | 8.29 |
| CHEMBL5596380 | — | — | 1 | - |
| CHEMBL466336 | — | — | 1 | - |
| CHEMBL5598500 | — | — | 1 | - |
| CHEMBL469163 | — | — | 1 | - |
| CHEMBL511584 | — | — | 1 | - |
| CHEMBL5596806 | — | — | 1 | - |
| CHEMBL5596425 | — | — | 1 | - |
| CHEMBL5598122 | — | — | 1 | - |
| CHEMBL5596859 | — | — | 1 | - |
| CHEMBL5597101 | — | — | 1 | - |
| CHEMBL5596805 | — | — | 1 | - |
| CHEMBL5597157 | — | — | 1 | - |
| CHEMBL5598322 | — | — | 1 | - |
| CHEMBL5597314 | — | — | 1 | - |
| CHEMBL5597224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222735 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5596859 | — | Inhibition | - | % | - | |
| CHEMBL466336 | — | Inhibition | - | % | - | |
| CHEMBL222735 | — | Inhibition | - | % | - | |
| CHEMBL5598500 | — | Inhibition | - | % | - | |
| CHEMBL469163 | — | Inhibition | - | % | - | |
| CHEMBL511584 | — | Inhibition | - | % | - | |
| CHEMBL5596806 | — | Inhibition | - | % | - | |
| CHEMBL5596425 | — | Inhibition | - | % | - | |
| CHEMBL5596380 | — | Inhibition | - | % | - | |
| CHEMBL5597101 | — | Inhibition | - | % | - | |
| CHEMBL5596805 | — | Inhibition | - | % | - | |
| CHEMBL5597157 | — | Inhibition | - | % | - | |
| CHEMBL5598322 | — | Inhibition | - | % | - | |
| CHEMBL5597314 | — | Inhibition | - | % | - | |
| CHEMBL5597224 | — | Inhibition | - | % | - | |
| CHEMBL5598122 | — | Inhibition | - | % | - |