Assay Detail
Binding
CHEMBL5587626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAO-B using p-tyramine as substrate incubated for 30 mins by Amplex Red reagent based fluorescence analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenylstyrylpyrimidine derivatives as potential multipotent therapeutics for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.52 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 7.10 |
| CHEMBL5597896 | — | — | 1 | 5.31 |
| CHEMBL5598412 | — | — | 1 | 5.14 |
| CHEMBL5597283 | — | — | 1 | 5.09 |
| CHEMBL5596371 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5597896 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5598412 | — | IC50 | = | 7265.0 | nM | 5.14 |
| CHEMBL5597283 | — | IC50 | = | 8152.0 | nM | 5.09 |
| CHEMBL5596371 | — | IC50 | = | 10892.0 | nM | 4.96 |