Assay Detail
Functional
CHEMBL5587787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evo312: An Evodiamine Analog and Novel PKCβI Inhibitor with Potent Antitumor Activity in Gemcitabine-Resistant Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.10 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598530 | — | — | 1 | 6.12 |
| CHEMBL5597588 | — | — | 1 | 6.03 |
| CHEMBL5597281 | — | — | 1 | 5.98 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.90 |
| CHEMBL5597569 | — | — | 1 | 5.88 |
| CHEMBL5597771 | — | — | 1 | 5.70 |
| CHEMBL5597741 | — | — | 1 | 5.65 |
| CHEMBL5598419 | — | — | 1 | 5.40 |
| CHEMBL5596687 | — | — | 1 | 5.35 |
| CHEMBL300138 | ENZASTAURIN | 3.0 | 1 | 5.18 |
| CHEMBL463165 | — | — | 1 | 5.18 |
| CHEMBL5598045 | — | — | 1 | 5.17 |
| CHEMBL5596961 | — | — | 1 | 5.16 |
| CHEMBL5596088 | — | — | 1 | 5.06 |
| CHEMBL5598244 | — | — | 1 | 5.03 |
| CHEMBL5597530 | — | — | 1 | 4.97 |
| CHEMBL5596634 | — | — | 1 | 4.96 |
| CHEMBL5596185 | — | — | 1 | 4.95 |
| CHEMBL4782533 | — | — | 1 | 4.90 |
| CHEMBL5596346 | — | — | 1 | 4.86 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.74 |
| CHEMBL5597214 | — | — | 1 | 4.72 |
| CHEMBL5598493 | — | — | 1 | 4.53 |
| CHEMBL5597899 | — | — | 1 | 4.50 |
| CHEMBL5597151 | — | — | 1 | 4.50 |
| CHEMBL5597757 | — | — | 1 | 4.50 |
| CHEMBL5590923 | — | — | 1 | 4.42 |
| CHEMBL5596095 | — | — | 1 | 4.36 |
| CHEMBL5597517 | — | — | 1 | 4.33 |
| CHEMBL5596786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598530 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5597588 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5597281 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5597569 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5597771 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5597741 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5598419 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5596687 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL300138 | ENZASTAURIN | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL463165 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL5598045 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5596961 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL5596088 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5598244 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL5597530 | — | IC50 | = | 10730.0 | nM | 4.97 |
| CHEMBL5596634 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL5596185 | — | IC50 | = | 11260.0 | nM | 4.95 |
| CHEMBL4782533 | — | IC50 | = | 12570.0 | nM | 4.90 |
| CHEMBL5596346 | — | IC50 | = | 13680.0 | nM | 4.86 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 18260.0 | nM | 4.74 |
| CHEMBL5597214 | — | IC50 | = | 18970.0 | nM | 4.72 |
| CHEMBL5598493 | — | IC50 | = | 29250.0 | nM | 4.53 |
| CHEMBL5597899 | — | IC50 | = | 31640.0 | nM | 4.50 |
| CHEMBL5597151 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL5597757 | — | IC50 | = | 31550.0 | nM | 4.50 |
| CHEMBL5590923 | — | IC50 | = | 38350.0 | nM | 4.42 |
| CHEMBL5596095 | — | IC50 | = | 43980.0 | nM | 4.36 |
| CHEMBL5597517 | — | IC50 | = | 47170.0 | nM | 4.33 |
| CHEMBL5597793 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5597837 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597021 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5598177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597121 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4848205 | — | IC50 | <= | 50.0 | nM | - |
| CHEMBL5596940 | — | IC50 | <= | 80.0 | nM | - |
| CHEMBL5590882 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5598382 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5270892 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5598029 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5597979 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596954 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596786 | — | IC50 | > | 50000.0 | nM | - |