Assay Detail
Binding
CHEMBL5587980
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Binding affinity to human recombinant CA II assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigating Active Site Binding of Ligands to High and Low Activity Carbonic Anhydrase Enzymes Using Native Mass Spectrometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.80 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.54 |
| CHEMBL878 | METOLAZONE | 4.0 | 1 | 5.70 |
| CHEMBL1072 | BUMETANIDE | 4.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL878 | METOLAZONE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1072 | BUMETANIDE | Ki | = | 6980.0 | nM | 5.16 |