Assay Detail
Binding
CHEMBL5587989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Pyrazolo[1,5-<i>a</i>]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.75 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598454 | — | — | 1 | 8.80 |
| CHEMBL5590633 | — | — | 1 | 8.52 |
| CHEMBL5598309 | — | — | 1 | 8.48 |
| CHEMBL5597159 | — | — | 1 | 8.40 |
| CHEMBL5596579 | — | — | 1 | 8.29 |
| CHEMBL5596530 | — | — | 1 | 8.28 |
| CHEMBL5597293 | — | — | 1 | 8.22 |
| CHEMBL5597786 | — | — | 1 | 8.10 |
| CHEMBL5597218 | — | — | 1 | 8.04 |
| CHEMBL5598183 | — | — | 1 | 8.01 |
| CHEMBL5598560 | — | — | 1 | 7.97 |
| CHEMBL5596735 | — | — | 1 | 7.80 |
| CHEMBL5597286 | — | — | 1 | 7.78 |
| CHEMBL5596114 | — | — | 1 | 7.75 |
| CHEMBL5590113 | — | — | 1 | 7.69 |
| CHEMBL5596364 | — | — | 1 | 7.67 |
| CHEMBL5597371 | — | — | 1 | 7.57 |
| CHEMBL5597160 | — | — | 1 | 7.49 |
| CHEMBL5590382 | — | — | 1 | 7.45 |
| CHEMBL5596470 | — | — | 1 | 7.40 |
| CHEMBL5596476 | — | — | 1 | 7.20 |
| CHEMBL5596611 | — | — | 1 | 7.18 |
| CHEMBL5597610 | — | — | 1 | 7.16 |
| CHEMBL5596396 | — | — | 1 | 6.96 |
| CHEMBL5597903 | — | — | 1 | 6.94 |
| CHEMBL5596701 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598454 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5590633 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5598309 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5597159 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5596579 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5596530 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5597293 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5597786 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5597218 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5598183 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5598560 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5596735 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5597286 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5596114 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL5590113 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL5596364 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL5597371 | — | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL5597160 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL5590382 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL5596470 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL5596476 | — | IC50 | = | 62.6 | nM | 7.20 |
| CHEMBL5596611 | — | IC50 | = | 66.2 | nM | 7.18 |
| CHEMBL5597610 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL5596396 | — | IC50 | = | 108.9 | nM | 6.96 |
| CHEMBL5597903 | — | IC50 | = | 114.2 | nM | 6.94 |
| CHEMBL5596701 | — | IC50 | = | 521.9 | nM | 6.28 |