Assay Detail
Functional
CHEMBL5588044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCC1569 cells incubated for 48 to 96 hrs by CCK-8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1569 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of <i>CCNE1</i>-Amplified Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.96 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | 2.0 | 1 | 7.22 |
| CHEMBL5598020 | — | — | 1 | 6.60 |
| CHEMBL5596480 | — | — | 1 | 6.54 |
| CHEMBL5596280 | — | — | 1 | 6.54 |
| CHEMBL5596250 | — | — | 1 | 6.33 |
| CHEMBL5597456 | — | — | 1 | 6.11 |
| CHEMBL5598294 | — | — | 1 | 6.10 |
| CHEMBL5598459 | — | — | 1 | 5.93 |
| CHEMBL5598426 | — | — | 1 | 5.86 |
| CHEMBL5597843 | — | — | 1 | 5.78 |
| CHEMBL5597451 | — | — | 1 | 5.78 |
| CHEMBL5598536 | — | — | 1 | 5.74 |
| CHEMBL5597660 | — | — | 1 | 5.66 |
| CHEMBL5597966 | — | — | 1 | 5.60 |
| CHEMBL5596854 | — | — | 1 | 5.42 |
| CHEMBL5597465 | — | — | 1 | 5.11 |
| CHEMBL5596068 | — | — | 1 | 5.02 |
| CHEMBL5596497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5598020 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5596480 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5596280 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5596250 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5597456 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5598294 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5598459 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5598426 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5597843 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5597451 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5598536 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5597660 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5597966 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL5596854 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5597465 | — | IC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL5596068 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL5596497 | — | IC50 | > | 20000.0 | nM | - |