Assay Detail
Functional
CHEMBL5588085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse C26 cells harboring KRAS G12D mutant incubated for 72 hrs by CCK8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | C-26 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1<i>H</i>-benzo[<i>d</i>]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.14 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596553 | — | — | 1 | 7.96 |
| CHEMBL5597799 | — | — | 1 | 7.25 |
| CHEMBL5597316 | — | — | 1 | 7.02 |
| CHEMBL5597586 | — | — | 1 | 6.82 |
| CHEMBL5596257 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596553 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5597799 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5597316 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5597586 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5596257 | — | IC50 | = | 226.0 | nM | 6.65 |