Assay Detail
Binding
CHEMBL5588326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human recombinant his-sumo tagged ClpP expressed in Escherichia coli BL21 (DE3) using FITC-casein as substrate preincubated for 30 mins followed by substrate addition and measured every 60 secs for 30 mins by fluorescence based microplate reader analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CHEMBL4523305) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.57 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597011 | — | — | 1 | 7.10 |
| CHEMBL5596220 | — | — | 1 | 7.05 |
| CHEMBL5597441 | — | — | 1 | 7.05 |
| CHEMBL5596597 | — | — | 1 | 6.92 |
| CHEMBL5598515 | — | — | 1 | 6.89 |
| CHEMBL5597008 | — | — | 1 | 6.89 |
| CHEMBL5597414 | — | — | 1 | 6.85 |
| CHEMBL5597713 | — | — | 1 | 6.64 |
| CHEMBL5598503 | — | — | 1 | 6.62 |
| CHEMBL5597740 | — | — | 1 | 6.58 |
| CHEMBL5596563 | — | — | 1 | 6.58 |
| CHEMBL5596404 | — | — | 1 | 6.50 |
| CHEMBL5287669 | — | — | 1 | 6.41 |
| CHEMBL5596606 | — | — | 1 | 6.38 |
| CHEMBL5590920 | — | — | 1 | 6.32 |
| CHEMBL5598320 | — | — | 1 | 6.28 |
| CHEMBL4650311 | ONC-206 | 1.0 | 1 | 6.25 |
| CHEMBL5597516 | — | — | 1 | 6.16 |
| CHEMBL5596968 | — | — | 1 | 6.07 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597011 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5596220 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5597441 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5596597 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5598515 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5597008 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5597414 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5597713 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5598503 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5597740 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5596563 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5596404 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5287669 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5596606 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5590920 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5598320 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4650311 | ONC-206 | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5597516 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5596968 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4297310 | DORDAVIPRONE | EC50 | = | 1720.0 | nM | 5.76 |