Assay Detail
Binding
CHEMBL5588330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant N-terminal 6his/sumo tagged ClpP (57 to 277 residues) assessed as dissociation constant incubated for 30 mins by MST assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CHEMBL4523305) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.28 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5597011 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5597011 | — | Kd | = | 53.0 | nM | 7.28 |