Assay Detail
Functional
CHEMBL5588487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells incubated for 72 hrs by celltiter-glo luminescent assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.58 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3656841 | — | — | 1 | 7.70 |
| CHEMBL5598116 | — | — | 1 | 5.94 |
| CHEMBL5597266 | — | — | 1 | 5.71 |
| CHEMBL5596602 | — | — | 1 | 5.71 |
| CHEMBL5598168 | — | — | 1 | 5.61 |
| CHEMBL5598054 | — | — | 1 | 5.12 |
| CHEMBL5597605 | — | — | 1 | 5.12 |
| CHEMBL5598317 | — | — | 1 | 5.12 |
| CHEMBL5598550 | — | — | 1 | 4.89 |
| CHEMBL5597396 | — | — | 1 | 4.88 |
| CHEMBL5598531 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3656841 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5598116 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5597266 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL5596602 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5598168 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL5598054 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL5597605 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL5598317 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL5598550 | — | IC50 | = | 12990.0 | nM | 4.89 |
| CHEMBL5597396 | — | IC50 | = | 13230.0 | nM | 4.88 |
| CHEMBL5598531 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |