Assay Detail
Binding
CHEMBL5588798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from spindle incubated for 2 hrs by Hoechst/DAPI staining based imaging analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aurora kinase A/Targeting protein for Xklp2 (CHEMBL3883304) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Selective Aurora A-TPX2 Interaction Inhibitors Have <i>In Vivo</i> Efficacy as Targeted Antimitotic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.36 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596916 | — | — | 1 | 5.89 |
| CHEMBL5598288 | — | — | 1 | 5.66 |
| CHEMBL5596260 | — | — | 1 | 5.46 |
| CHEMBL5597168 | — | — | 1 | 5.26 |
| CHEMBL5597404 | — | — | 1 | 5.21 |
| CHEMBL5596300 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596916 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5598288 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5596260 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5597168 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5597404 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5596300 | — | EC50 | = | 20000.0 | nM | 4.70 |