Assay Detail
Binding
CHEMBL5588858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GST tagged LXRbeta (unknown origin) using SRC1 as coactivator peptide incubated for 1 hr by coactivator recruitment based TR-FRET assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human <i>APOE3/APOE4</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.71 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 6.96 |
| CHEMBL5597982 | — | — | 1 | 6.82 |
| CHEMBL5596248 | — | — | 1 | 6.29 |
| CHEMBL5597153 | — | — | 1 | 6.25 |
| CHEMBL5596815 | — | — | 1 | 6.24 |
| CHEMBL5597394 | — | — | 1 | 6.11 |
| CHEMBL5598250 | — | — | 1 | 5.82 |
| CHEMBL5596939 | — | — | 1 | 5.82 |
| CHEMBL5596386 | — | — | 1 | 5.72 |
| CHEMBL5597291 | — | — | 1 | 5.70 |
| CHEMBL5598331 | — | — | 1 | 5.64 |
| CHEMBL5597028 | — | — | 1 | 5.35 |
| CHEMBL5596392 | — | — | 1 | 4.96 |
| CHEMBL5590383 | — | — | 1 | 4.89 |
| CHEMBL5590706 | — | — | 1 | 4.89 |
| CHEMBL5597319 | — | — | 1 | 4.82 |
| CHEMBL5596811 | — | — | 1 | 4.82 |
| CHEMBL5596907 | — | — | 1 | - |
| CHEMBL5596592 | — | — | 1 | - |
| CHEMBL5597943 | — | — | 1 | - |
| CHEMBL5598279 | — | — | 1 | - |
| CHEMBL5596520 | — | — | 1 | - |
| CHEMBL5597106 | — | — | 1 | - |
| CHEMBL5598324 | — | — | 1 | - |
| CHEMBL5590617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5597982 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5596248 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5597153 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5596815 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5597394 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5598250 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5596939 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5596386 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5597291 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5598331 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5597028 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5596392 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5590383 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5590706 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5597319 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5596811 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5596907 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5596592 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5597943 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5598279 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5596520 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5597106 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5598324 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5590617 | — | EC50 | > | 25000.0 | nM | - |