Assay Detail
Binding
CHEMBL5589302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at full length GST-tagged human THR-beta LBD incubated for 1 hr in presence of fluorescein labeled SRC2-2 peptide by Lanthascreen TR-FRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.18 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596442 | — | — | 1 | 7.72 |
| CHEMBL5597482 | — | — | 1 | 7.20 |
| CHEMBL3261331 | RESMETIROM | 4.0 | 1 | 7.14 |
| CHEMBL5598332 | — | — | 1 | 6.20 |
| CHEMBL5597989 | — | — | 1 | 6.13 |
| CHEMBL5598543 | — | — | 1 | 6.04 |
| CHEMBL5598441 | — | — | 1 | 5.57 |
| CHEMBL5596341 | — | — | 1 | 5.05 |
| CHEMBL5598346 | — | — | 1 | 4.54 |
| CHEMBL5597744 | — | — | 1 | - |
| CHEMBL5596618 | — | — | 1 | - |
| CHEMBL5589816 | — | — | 1 | - |
| CHEMBL5590206 | — | — | 1 | - |
| CHEMBL5596268 | — | — | 1 | - |
| CHEMBL5597882 | — | — | 1 | - |
| CHEMBL5597130 | — | — | 1 | - |
| CHEMBL5590707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596442 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5597482 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3261331 | RESMETIROM | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5598332 | — | EC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5597989 | — | EC50 | = | 738.0 | nM | 6.13 |
| CHEMBL5598543 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5598441 | — | EC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL5596341 | — | EC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL5598346 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5597744 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5596618 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5589816 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5590206 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5596268 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5597882 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5597130 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5590707 | — | EC50 | > | 50000.0 | nM | - |