Assay Detail
Functional
CHEMBL5589310
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Effect on CPT1A gene expression in human Huh-7 cells measured for 24 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.66 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596442 | — | — | 1 | 8.40 |
| CHEMBL5597482 | — | — | 1 | 8.05 |
| CHEMBL3261331 | RESMETIROM | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596442 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5597482 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3261331 | RESMETIROM | EC50 | = | 303.0 | nM | 6.52 |