Assay Detail
ADMET
CHEMBL5589325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C8 in human liver microsomes at 10 uM in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.05 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261331 | RESMETIROM | 4.0 | 1 | 6.05 |
| CHEMBL5597482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261331 | RESMETIROM | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5597482 | — | IC50 | = | 112000.0 | nM | - |