Assay Detail
Binding
CHEMBL5608451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5A (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Opportunities and perspectives of small molecular phosphodiesterase inhibitors in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.01 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435044 | — | — | 1 | 9.82 |
| CHEMBL5271210 | — | — | 1 | 8.79 |
| CHEMBL4208487 | — | — | 1 | 8.30 |
| CHEMBL5613113 | — | — | 1 | 8.10 |
| CHEMBL4212186 | — | — | 1 | 7.96 |
| CHEMBL5288336 | — | — | 1 | 7.48 |
| CHEMBL4641729 | — | — | 1 | 7.44 |
| CHEMBL4217364 | — | — | 1 | 7.22 |
| CHEMBL5184593 | — | — | 1 | 6.94 |
| CHEMBL5275356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435044 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5271210 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL4208487 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5613113 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4212186 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5288336 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL4641729 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4217364 | — | IC50 | = | 60.3 | nM | 7.22 |
| CHEMBL5184593 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5275356 | — | IC50 | = | 3.2 | nM | - |