Assay Detail
Functional
CHEMBL5608593
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An insight into sustainable and green chemistry approaches for the synthesis of quinoline derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303201 | CATEQUENTINIB | 3.0 | 1 | 4.77 |
| CHEMBL5613362 | — | — | 1 | 4.70 |
| CHEMBL5612382 | — | — | 1 | 4.69 |
| CHEMBL11417 | STREPTONIGRIN | 2.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303201 | CATEQUENTINIB | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5613362 | — | IC50 | = | 19760.0 | nM | 4.70 |
| CHEMBL5612382 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL11417 | STREPTONIGRIN | IC50 | = | 30500.0 | nM | 4.52 |