Assay Detail
Functional
CHEMBL5608779
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Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
50
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-30 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.35 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612773 | — | — | 2 | 7.89 |
| CHEMBL5614128 | — | — | 1 | 7.85 |
| CHEMBL5611956 | — | — | 1 | 7.68 |
| CHEMBL5612387 | — | — | 1 | 7.19 |
| CHEMBL5613572 | — | — | 1 | 7.04 |
| CHEMBL5612680 | — | — | 1 | 6.99 |
| CHEMBL5612523 | — | — | 1 | 6.91 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.77 |
| CHEMBL5612345 | — | — | 1 | 6.75 |
| CHEMBL5613492 | — | — | 1 | 6.71 |
| CHEMBL5612595 | — | — | 1 | 6.65 |
| CHEMBL5613480 | — | — | 1 | 6.61 |
| CHEMBL5612685 | — | — | 1 | 6.54 |
| CHEMBL5613687 | — | — | 1 | 6.46 |
| CHEMBL5611938 | — | — | 1 | 6.45 |
| CHEMBL5613083 | — | — | 1 | 6.39 |
| CHEMBL5613290 | — | — | 1 | 6.31 |
| CHEMBL5613218 | — | — | 1 | 6.15 |
| CHEMBL5613676 | — | — | 1 | 6.14 |
| CHEMBL5613886 | — | — | 1 | 5.99 |
| CHEMBL5614183 | — | — | 1 | 5.87 |
| CHEMBL5612730 | — | — | 1 | 5.82 |
| CHEMBL5613317 | — | — | 1 | 5.78 |
| CHEMBL5613487 | — | — | 1 | 5.50 |
| CHEMBL5613679 | — | — | 1 | 5.50 |
| CHEMBL5613974 | — | — | 1 | 5.47 |
| CHEMBL5612065 | — | — | 1 | 5.34 |
| CHEMBL5614330 | — | — | 1 | 5.20 |
| CHEMBL5612459 | — | — | 1 | 5.19 |
| CHEMBL5614151 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612773 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5612773 | — | IC50 | = | 13.15 | nM | 7.88 |
| CHEMBL5614128 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5611956 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5612387 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5613572 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5612680 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5612523 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL5612345 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5613492 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5612595 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL5613480 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL5612685 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL5613687 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL5611938 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL5613083 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL5613290 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL5613218 | — | IC50 | = | 714.0 | nM | 6.15 |
| CHEMBL5613676 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL5613886 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL5614183 | — | IC50 | = | 1351.0 | nM | 5.87 |
| CHEMBL5612730 | — | IC50 | = | 1508.0 | nM | 5.82 |
| CHEMBL5613317 | — | IC50 | = | 1649.0 | nM | 5.78 |
| CHEMBL5613679 | — | IC50 | = | 3167.0 | nM | 5.50 |
| CHEMBL5613487 | — | IC50 | = | 3189.0 | nM | 5.50 |
| CHEMBL5613974 | — | IC50 | = | 3399.0 | nM | 5.47 |
| CHEMBL5612065 | — | IC50 | = | 4572.0 | nM | 5.34 |
| CHEMBL5614330 | — | IC50 | = | 6371.0 | nM | 5.20 |
| CHEMBL5612459 | — | IC50 | = | 6411.0 | nM | 5.19 |
| CHEMBL5614151 | — | IC50 | = | 7529.0 | nM | 5.12 |
| CHEMBL5611981 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5613358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612832 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613045 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612310 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5612733 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5613896 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5612721 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612980 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5614074 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL5611922 | — | IC50 | > | 2506.0 | nM | - |