Assay Detail
Functional
CHEMBL5609197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.86 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612012 | — | — | 1 | 9.51 |
| CHEMBL444724 | — | — | 1 | 9.11 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.92 |
| CHEMBL5613733 | — | — | 1 | 8.91 |
| CHEMBL5614173 | — | — | 1 | 8.88 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.85 |
| CHEMBL5612097 | — | — | 1 | 8.69 |
| CHEMBL5614105 | — | — | 1 | 8.56 |
| CHEMBL5612471 | — | — | 1 | 8.54 |
| CHEMBL5613654 | — | — | 1 | 8.30 |
| CHEMBL5612409 | — | — | 1 | 8.23 |
| CHEMBL498221 | — | — | 1 | 8.21 |
| CHEMBL5613033 | — | — | 1 | 8.04 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.99 |
| CHEMBL5613720 | — | — | 1 | 7.85 |
| CHEMBL5614335 | — | — | 1 | 7.63 |
| CHEMBL5612420 | — | — | 1 | 7.60 |
| CHEMBL5612238 | — | — | 1 | 7.50 |
| CHEMBL5613474 | — | — | 1 | 7.46 |
| CHEMBL5613459 | — | — | 1 | 7.42 |
| CHEMBL5612419 | — | — | 1 | 7.41 |
| CHEMBL496792 | — | — | 1 | 7.35 |
| CHEMBL5612158 | — | — | 1 | 7.33 |
| CHEMBL5612491 | — | — | 1 | 7.29 |
| CHEMBL5613006 | — | — | 1 | 7.28 |
| CHEMBL5612840 | — | — | 1 | 7.23 |
| CHEMBL5614102 | — | — | 1 | 7.04 |
| CHEMBL5613588 | — | — | 1 | 6.99 |
| CHEMBL5613227 | — | — | 1 | 6.76 |
| CHEMBL5614263 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612012 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL444724 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL5613733 | — | IC50 | = | 1.224 | nM | 8.91 |
| CHEMBL5614173 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL5612097 | — | IC50 | = | 2.06 | nM | 8.69 |
| CHEMBL5614105 | — | IC50 | = | 2.72 | nM | 8.56 |
| CHEMBL5612471 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL5613654 | — | IC50 | = | 4.95 | nM | 8.30 |
| CHEMBL5612409 | — | IC50 | = | 5.83 | nM | 8.23 |
| CHEMBL498221 | — | IC50 | = | 6.22 | nM | 8.21 |
| CHEMBL5613033 | — | IC50 | = | 9.02 | nM | 8.04 |
| CHEMBL107 | COLCHICINE | IC50 | = | 10.23 | nM | 7.99 |
| CHEMBL5613720 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL5614335 | — | IC50 | = | 23.19 | nM | 7.63 |
| CHEMBL5612420 | — | IC50 | = | 25.33 | nM | 7.60 |
| CHEMBL5612238 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5613474 | — | IC50 | = | 34.93 | nM | 7.46 |
| CHEMBL5613459 | — | IC50 | = | 37.97 | nM | 7.42 |
| CHEMBL5612419 | — | IC50 | = | 39.25 | nM | 7.41 |
| CHEMBL496792 | — | IC50 | = | 44.91 | nM | 7.35 |
| CHEMBL5612158 | — | IC50 | = | 46.85 | nM | 7.33 |
| CHEMBL5612491 | — | IC50 | = | 50.72 | nM | 7.29 |
| CHEMBL5613006 | — | IC50 | = | 52.88 | nM | 7.28 |
| CHEMBL5612840 | — | IC50 | = | 58.72 | nM | 7.23 |
| CHEMBL5614102 | — | IC50 | = | 91.91 | nM | 7.04 |
| CHEMBL5613588 | — | IC50 | = | 101.41 | nM | 6.99 |
| CHEMBL5613227 | — | IC50 | = | 171.6 | nM | 6.76 |
| CHEMBL5614263 | — | IC50 | = | 264.53 | nM | 6.58 |
| CHEMBL5613993 | — | IC50 | = | 741.1 | nM | 6.13 |
| CHEMBL5613201 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613893 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614228 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612770 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613592 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612859 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614199 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613032 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613904 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614275 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612352 | — | IC50 | > | 1000.0 | nM | - |